Recombinant Human Ficolin-2 (FCN2)

The expression region of this recombinant Human FCN2 covers amino acids 26-313. The expected molecular weight for the FCN2 protein is calculated to be 33.4 kDa. Expression of this FCN2 protein is conducted in yeast. The FCN2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant FCN2 protein during the following stages.Human Ficolin-2 (FCN2) is a soluble pattern recognition receptor that plays a crucial role in the innate immune system. Upon binding to microbial surfaces, FCN2 activates the lectin pathway of the complement system. It initiates the cascade leading to the formation of the membrane attack complex, promoting opsonization and lysis of pathogens. FCN2 is involved in the defense against a variety of pathogens, including bacteria, viruses, and fungi. Its role in complement activation contributes to the clearance of pathogens and modulates the immune response. Variations in the FCN2 gene have been associated with susceptibility or resistance to certain infections and autoimmune diseases, highlighting the importance of FCN2 in immune regulation. Research on FCN2 may have implications for the development of therapies targeting infectious diseases and immune-related disorders.