Recombinant Human Follistatin (FST)

Uniprot Id

P19883

Target Species

Human

Target Name

FST

Target Full Name

Follistatin

Target Function

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

Target Subcellular Location

Secreted.

Target Tissue Specificity

Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronoun

Target Synonyms

Activin binding protein ; Activin-binding protein; Follistatin; FS; fst; FST_HUMAN; Human follistatin gene

Target Background

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.