Recombinant Human Forkhead box protein G1 (FOXG1)

Uniprot Id

P55316

Target Species

Human

Target Name

FOXG1

Target Full Name

Forkhead box protein G1

Target Function

Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.

Target Involvement

Rett syndrome congenital variant (RTTCV)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expression is restricted to the neurons of the developing telencephalon.

Target Research Area

Others

Target Synonyms

BF-1; BF-2; BF1; BF2; Brain factor 1; Brain factor 2; FHKL; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; Forkhead box protein G1; Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; Forkhead like 1; Forkhead like 2; Forkhead like 3; Forkhead like 4; Forkhead-related protein FKHL1; Forkhead-related protein FKHL2; Forkhead-related protein FKHL3; FOXG1; FOXG1_HUMAN; FOXG1A; FOXG1B; FOXG1C; HBF 1; HBF G2; hBF-2; HBF2; HFK1; HFK2; HFK3; KHL2; Oncogene QIN; QIN

Target Background

This locus encodes a member of the fork-head transcription factor family. The encoded protein, which functions as a transcriptional repressor, is highly expressed in neural tissues during brain development. Mutations at this locus have been associated with Rett syndrome and a diverse spectrum of neurodevelopmental disorders defined as part of the FOXG1 syndrome. This gene is disregulated in many types of cancer and is the target of multiple microRNAs that regulate the proliferation of tumor cells.