Home Products Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 (FGD5), Truncated

Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 (FGD5), Truncated

ACP15968

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Specifications

Cat.No	ACP15968	Target Name	FGD5
Target Synonyms	FGD5; ZFYVE23FYVE; RhoGEF and PH domain-containing protein 5; Zinc finger FYVE domain-containing protein 23	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q6ZNL6

Background Information

Uniprot Id

Q6ZNL6
Target Species

Human
Target Name

FGD5
Target Full Name

FYVE, RhoGEF and PH domain-containing protein 5
Target Function

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
Target Tissue Specificity

Expressed in endothelial cells (at protein level).
Target Synonyms

FGD5; ZFYVE23FYVE; RhoGEF and PH domain-containing protein 5; Zinc finger FYVE domain-containing protein 23
Target Background

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Located in plasma membrane.

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Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 (FGD5), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 (FGD5), Truncated Now

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