Recombinant Human G-protein coupled receptor 124 (GPR124), Truncated

Uniprot Id

Q96PE1

Target Species

Human

Target Name

ADGRA2

Target Full Name

Adhesion G protein-coupled receptor A2

Target Function

Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly. Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell projection, filopodium.

Target Protein Families

G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily

Target Tissue Specificity

Expressed in endothelial cells (at protein level). Abundantly expressed in heart, placenta, ovary, small intestine, and colon.

Target Synonyms

DKFZp434C211; DKFZp434J0911; FLJ14390; G protein coupled receptor 124; G-protein coupled receptor 124; GP124_HUMAN; GPR 124; Gpr124; KIAA1531; TEM 5; TEM5; Tumor endothelial marker 5; Tumor endothelial marker 5 precursor