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| Cat.No | ACP02979 | Target Name | GPR161 |
|---|---|---|---|
| Target Synonyms | GPR161; G-protein coupled receptor 161; G-protein coupled receptor RE2 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-28aa |
| Mol Weight | 30.0kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N6U8 |
|---|
Uniprot Id
Q8N6U8
Target Species
Human
Target Name
GPR161
Target Full Name
G-protein coupled receptor 161
Target Function
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown.
Target Subcellular Location
Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family
Target Research Area
Signal Transduction
Target Synonyms
GPR161; G-protein coupled receptor 161; G-protein coupled receptor RE2
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