Recombinant Human G protein-coupled receptor kinase 6 (GRK6)

Uniprot Id

P43250

Target Species

Human

Target Name

GRK6

Target Full Name

G protein-coupled receptor kinase 6

Target Function

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Target Subcellular Location

Membrane; Lipid-anchor.

Target Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily

Target Tissue Specificity

Widely expressed.

Target Synonyms

FLJ32135; G protein coupled receptor kinase 6; G protein coupled receptor kinase GRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; Gprk6; Grk6; GRK6_HUMAN

Target Background

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.