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| Cat.No | ACP07394 | Target Name | GJB4 |
|---|---|---|---|
| Target Synonyms | GJB4; Gap junction beta-4 protein; Connexin-30.3; Cx30.3 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NTQ9 |
|---|
Uniprot Id
Q9NTQ9
Target Species
Human
Target Name
GJB4
Target Full Name
Gap junction beta-4 protein
Target Function
Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Target Involvement
Erythrokeratodermia variabilis et progressiva 2 (EKVP2)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Target Protein Families
Connexin family, Beta-type (group I) subfamily
Target Synonyms
GJB4; Gap junction beta-4 protein; Connexin-30.3; Cx30.3
Target Background
This gene encodes a transmembrane connexin protein that is a component of gap junctions. Mutations in this gene have been associated with erythrokeratodermia variabilis, progressive symmetric erythrokeratoderma and hearing impairment.
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