Recombinant Human GDNF family receptor alpha-1 (GFRA1)

Cat.No	ACP22767	Target Name	GFRA1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	25-429	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP22767

Target Name

GFRA1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

25-429

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P56159

Background Information

Uniprot Id

P56159
Target Species

Human
Target Name

GFRA1
Target Full Name

GDNF family receptor alpha-1
Target Function

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus, trans-Golgi network. Endosome. Endosome, multivesicular body.
Target Protein Families

GDNFR family
Target Synonyms

GDNF family receptor alpha 1; GDNF family receptor alpha-1; GDNF R; GDNF RA; GDNF receptor alpha; GDNF receptor alpha-1; GDNFR alpha 1; GDNFR alpha; GDNFR; GDNFR-alpha-1; GDNFRA; GDNFRalpha; GFR alpha 1; GFR alpha1; GFR-alpha-1; GFRA 1; Gfra1; GFRA1_HUMAN; GFRalpha1; Glial cell line derived neurotrophic factor receptor alpha; GPI linked anchor protein; MGC23045; PI linked cell surface accessory protein; RET 1L; RET ligand 1; RET1L; RETL 1; RETL1; TGF beta related neurotrophic factor receptor 1; TGF-beta-related neurotrophic factor receptor 1; TRNR 1; TRNR1
Target Background

This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Recombinant Human GDNF family receptor alpha-1 (GFRA1)

Specifications

Immunogen Information

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