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Amino acids 514-782 form the expressed segment for recombinant Human GSN. The expected molecular weight for the GSN protein is calculated to be 33.5 kDa. The GSN protein was expressed in e.coli. The GSN gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant GSN protein during the following stages.Human gelsolin (GSN) is a multifunctional actin-binding protein that regulates cytoskeletal dynamics and participates in various cellular processes. GSN severs and caps actin filaments, modulating actin cytoskeleton organization, which is crucial for cell motility, shape changes, and intracellular signaling. It also acts as a calcium-regulated actin filament-severing protein, influencing processes such as cell migration, phagocytosis, and apoptosis. GSN is implicated in cytoplasmic and extracellular functions, including modulation of inflammation and cell adhesion. Aberrations in GSN expression have been associated with certain diseases, including amyloidosis. Understanding its diverse roles in cellular physiology contributes to insights into its potential therapeutic applications.
Amino acids 514-782 form the expressed segment for recombinant Human GSN. The expected molecular weight for the GSN protein is calculated to be 33.5 kDa. The GSN protein was expressed in e.coli. The GSN gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant GSN protein during the following stages.Human gelsolin (GSN) is a multifunctional actin-binding protein that regulates cytoskeletal dynamics and participates in various cellular processes. GSN severs and caps actin filaments, modulating actin cytoskeleton organization, which is crucial for cell motility, shape changes, and intracellular signaling. It also acts as a calcium-regulated actin filament-severing protein, influencing processes such as cell migration, phagocytosis, and apoptosis. GSN is implicated in cytoplasmic and extracellular functions, including modulation of inflammation and cell adhesion. Aberrations in GSN expression have been associated with certain diseases, including amyloidosis. Understanding its diverse roles in cellular physiology contributes to insights into its potential therapeutic applications.
| Cat.No | ACP01889 | Target Name | GSN |
|---|---|---|---|
| Target Synonyms | AGEL;Actin-depolymerizing factor;ADF | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 514-782aa |
| Mol Weight | 33.5 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P06396 |
|---|
Uniprot Id
P06396
Target Species
Human
Target Name
GSN
Target Full Name
Gelsolin
Target Function
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Target Involvement
Amyloidosis 5 (AMYL5)
Target Subcellular Location
[Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 1]: Secreted.
Target Protein Families
Villin/gelsolin family
Target Tissue Specificity
Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Target Research Area
Signal Transduction
Target Synonyms
Actin depolymerizing factor; Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; GELS_HUMAN; Gelsolin; Gsn
Target Background
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
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