Recombinant Human Glucose-6-phosphate 1-dehydrogenase (G6PD)

Uniprot Id

P11413

Target Species

Human

Target Name

G6PD

Target Full Name

Glucose-6-phosphate 1-dehydrogenase

Target Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.

Target Involvement

Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA)

Target Subcellular Location

Cytoplasm, cytosol. Membrane; Peripheral membrane protein.

Target Protein Families

Glucose-6-phosphate dehydrogenase family

Target Tissue Specificity

Isoform Long is found in lymphoblasts, granulocytes and sperm.

Target Research Area

Cancer

Target Synonyms

G6PD; G6PD_HUMAN; G6PD1; G6pdx; Glucose 6 phosphate 1 dehydrogenase; Glucose 6 phosphate dehydrogenase; Glucose 6 phosphate dehydrogenase, G6PD; Glucose-6-phosphate 1-dehydrogenase; MET19; POS10; Zwf1p

Target Background

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.