Recombinant Human Glutamate receptor ionotropic, NMDA 2D (GRIN2D), Truncated

Uniprot Id

O15399

Target Species

Human

Target Name

GRIN2D

Target Full Name

Glutamate receptor ionotropic, NMDA 2D

Target Function

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.

Target Involvement

Epileptic encephalopathy, early infantile, 46 (EIEE46)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Target Protein Families

Glutamate-gated ion channel (TC 1.A.10.1) family, NR2D/GRIN2D subfamily

Target Synonyms

EB11; estrogen receptor binding CpG island; GluN2D; Glutamate [NMDA] receptor subunit epsilon 4; Glutamate [NMDA] receptor subunit epsilon-4; Glutamate receptor ionotropic; glutamate receptor ionotropic NMDA 2D; Glutamate receptor, ionotropic, N-methyl D-aspartate 2D; Grin2d; N methyl D aspartate receptor subtype 2D; N methyl d aspartate receptor subunit 2D; N-methyl D-aspartate receptor subtype 2D; NMDA 2D; NMDAR2D; NMDE4; NMDE4_HUMAN; NR2D