Recombinant Human Glutaminase kidney isoform, mitochondrial (GLS), Truncated

Cat.No	ACP03786	Target Name	GLS
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	616-669aa	Mol Weight	33.3kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03786

Target Name

GLS

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

616-669aa

Mol Weight

33.3kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O94925

Background Information

Uniprot Id

O94925
Target Species

Human
Target Name

GLS
Target Full Name

Glutaminase kidney isoform, mitochondrial
Target Function

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain.; Lacks catalytic activity.
Target Subcellular Location

[Isoform 1]: Mitochondrion. Cytoplasm, cytosol.; [Isoform 3]: Mitochondrion.; [Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix.; [Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix.
Target Protein Families

Glutaminase family
Target Tissue Specificity

Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and panc
Target Research Area

Signal Transduction, Metabolism
Target Synonyms

AAD20; DKFZp686O15119; FLJ10358; GAC; GAM; GLS; GLS1; GLSK_HUMAN; Glutaminase C; Glutaminase kidney isoform; Glutaminase phosphate activated; K-glutaminase; KGA; KIAA0838; L glutamine amidohydrolase; L-glutamine amidohydrolase; mitochondrial
Target Background

This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants.

Recombinant Human Glutaminase kidney isoform, mitochondrial (GLS), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Glutaminase kidney isoform, mitochondrial (GLS), Truncated Now

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