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| Cat.No | ACP01854 | Target Name | QPCT |
|---|---|---|---|
| Target Synonyms | Glutaminyl cyclase ;QC ;sQCGlutaminyl-tRNA cyclotransferaseGlutamyl cyclase ;EC | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 29-361aa |
| Mol Weight | 40.4 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16769 |
|---|
Uniprot Id
Q16769
Target Species
Human
Target Name
QPCT
Target Full Name
Glutaminyl-peptide cyclotransferase
Target Function
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
Target Subcellular Location
Secreted.
Target Protein Families
Glutaminyl-peptide cyclotransferase family
Target Research Area
Neuroscience
Target Synonyms
5730422A13Rik; EC; GCT; Glutaminyl cyclase; Glutaminyl peptide cyclotransferase; Glutaminyl tRNA cyclotransferase; Glutaminyl-peptide cyclotransferase; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; QC; qpct; QPCT_HUMAN; sQC
Target Background
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.
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