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| Cat.No | ACP22291 | Target Name | GSR |
|---|---|---|---|
| Target Synonyms | GLR1; GLUR; Glutathione reductase; Glutathione reductase mitochondrial; Glutathione reductase; mitochondrial; GR; Gr1; GRase; GRD 1; GRD1; GSHR_HUMAN; GSR; MGC78522 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 44-522 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P00390 |
|---|
Uniprot Id
P00390
Target Species
Human
Target Name
GSR
Target Full Name
Glutathione reductase, mitochondrial
Target Function
Maintains high levels of reduced glutathione in the cytosol.
Target Subcellular Location
[Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic]: Cytoplasm.
Target Protein Families
Class-I pyridine nucleotide-disulfide oxidoreductase family
Target Synonyms
GLR1; GLUR; Glutathione reductase; Glutathione reductase mitochondrial; Glutathione reductase; mitochondrial; GR; Gr1; GRase; GRD 1; GRD1; GSHR_HUMAN; GSR; MGC78522
Target Background
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
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