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| Cat.No | ACP05384 | Target Name | GLRA3 |
|---|---|---|---|
| Target Synonyms | GLRA 3; Glra3; GLRA3_HUMAN; Glycine receptor alpha 3 polypeptide; Glycine receptor alpha 3 subunit; Glycine receptor subunit alpha 3; Glycine receptor subunit alpha-3; Ligand gated ion channel | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75311 |
|---|
Uniprot Id
O75311
Target Species
Human
Target Name
GLRA3
Target Full Name
Glycine receptor subunit alpha-3
Target Function
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Contributes to increased pain perception in response to increased prostaglandin E2 levels. Plays a role in cellular responses to ethanol.
Target Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse. Cell membrane; Multi-pass membrane protein.
Target Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Glycine receptor (TC 1.A.9.3) subfamily, GLRA3 sub-subfamily
Target Tissue Specificity
Widely distributed throughout the central nervous system.
Target Synonyms
GLRA 3; Glra3; GLRA3_HUMAN; Glycine receptor alpha 3 polypeptide; Glycine receptor alpha 3 subunit; Glycine receptor subunit alpha 3; Glycine receptor subunit alpha-3; Ligand gated ion channel
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