Recombinant Human Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1), Truncated

Uniprot Id

Q9NS00

Target Species

Human

Target Name

C1GALT1

Target Full Name

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Target Function

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.

Target Subcellular Location

Membrane; Single-pass type II membrane protein.

Target Protein Families

Glycosyltransferase 31 family, Beta3-Gal-T subfamily

Target Tissue Specificity

Widely expressed. Highly expressed in kidney, heart, placenta and liver.

Target Synonyms

C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; EC 2.4.1.122; B3Gal-T8; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Beta-1,3-galactosyltransferase; Core 1 beta1,3-galactosyltransferase 1; C1GalT1; Core 1 beta3-Gal-T1

Target Background

The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.