Recombinant Human Glycylpeptide N-tetradecanoyltransferase 1 (NMT1)

Uniprot Id

P30419

Target Species

Human

Target Name

NMT1

Target Full Name

Glycylpeptide N-tetradecanoyltransferase 1

Target Function

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein.

Target Protein Families

NMT family

Target Tissue Specificity

Heart, gut, kidney, liver and placenta.

Target Synonyms

Alternative, short form NMT S; EC 2.3.1.97; Glycylpeptide N tetradecanoyltransferase 1; Glycylpeptide N-tetradecanoyltransferase 1; Long form, NMT L; Myristoyl CoA:protein N myristoyltransferase 1; Myristoyl-CoA:protein N-myristoyltransferase 1; N myristoyltransferase 1; NMT 1; NMT; nmt1; NMT1_HUMAN; Peptide N myristoyltransferase 1; Peptide N-myristoyltransferase 1; Type I N myristoyltransferase; Type I N-myristoyltransferase

Target Background

Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).