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| Cat.No | ACP08067 | Target Name | GRAMD2A |
|---|---|---|---|
| Target Synonyms | GRAMD2A; GRAMD2; GRAM domain-containing protein 2A | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IUY3 |
|---|
Uniprot Id
Q8IUY3
Target Species
Human
Target Name
GRAMD2A
Target Full Name
GRAM domain-containing protein 2A
Target Function
Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Peripheral membrane protein.
Target Synonyms
GRAMD2A; GRAMD2; GRAM domain-containing protein 2A
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