Recombinant Human Group XV phospholipase A2 (PLA2G15)

Cat.No	ACP14855	Target Name	PLA2G15
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	34-412	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP14855

Target Name

PLA2G15

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

34-412

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8NCC3

Background Information

Uniprot Id

Q8NCC3
Target Species

Human
Target Name

PLA2G15
Target Full Name

Lysosomal phospholipase A and acyltransferase
Target Function

Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments. Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines. Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide. Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress. Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance. At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines
Target Subcellular Location

Lysosome. Secreted. Membrane; Peripheral membrane protein.
Target Protein Families

AB hydrolase superfamily, Lipase family
Target Tissue Specificity

Detected in blood plasma (at protein level). Ubiquitous. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes
Target Synonyms

1 O acylceramide synthase; 1-O-acylceramide synthase; ACS; DKFZp564A0122; Group XV phospholipase A2; GXVPLA 2; GXVPLA2; LCAT like lysophospholipase; LCAT-like lysophospholipase; LLPL; LPLA 2; LPLA2; LYPLA 3; LYPLA3; Lysophospholipase 3 (lysosomal phospholipase A2); Lysophospholipase 3; Lysosomal phospholipase A2; OTTHUMP00000174859; PAG15_HUMAN; Phospholipase A2; group XV; PLA2G15; UNQ341/PRO540

Recombinant Human Group XV phospholipase A2 (PLA2G15)

Specifications

Immunogen Information

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