Recombinant Human Guanine nucleotide-binding protein G (I)/G (S)/G (T) subunit beta-1 (GNB1)

Uniprot Id

P62873

Target Species

Human

Target Name

GNB1

Target Full Name

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Target Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Target Involvement

Mental retardation, autosomal dominant 42 (MRD42)

Target Protein Families

WD repeat G protein beta family

Target Synonyms

Beta subunit signal transducing proteins GS/GI ; G protein beta 1 subunit ; GBB1; GBB1_HUMAN; gnb1; Guanine nucleotide binding protein (G protein) beta polypeptide 1; Guanine nucleotide binding protein beta 1 subunit; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Transducin beta chain 1

Target Background

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants.