Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The expression region of this recombinant Human GNAI1 covers amino acids 2-354. This GNAI1 protein is expected to have a theoretical molecular weight of 47.7 kDa. This GNAI1 recombinant protein is manufactured in e.coli. The GNAI1 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant GNAI1 protein in following stages of expression and purification.The human guanine nucleotide-binding protein G (i) subunit alpha-1 (GNAI1) is a member of the G-alpha subunit family, which plays a pivotal role in transducing signals from G-protein-coupled receptors (GPCRs) to intracellular effectors. GNAI1 inhibits adenylyl cyclase, leading to decreased cyclic AMP (cAMP) production and downstream signaling. This negatively regulates cellular processes such as neurotransmission, hormone secretion, and cell growth. GNAI1 is involved in various physiological functions, including the modulation of cardiovascular responses, neuronal activity, and immune cell function. Dysregulation of GNAI1 has been associated with several diseases, emphasizing its importance as a signaling molecule and a potential therapeutic target in various disorders.
The expression region of this recombinant Human GNAI1 covers amino acids 2-354. This GNAI1 protein is expected to have a theoretical molecular weight of 47.7 kDa. This GNAI1 recombinant protein is manufactured in e.coli. The GNAI1 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant GNAI1 protein in following stages of expression and purification.The human guanine nucleotide-binding protein G (i) subunit alpha-1 (GNAI1) is a member of the G-alpha subunit family, which plays a pivotal role in transducing signals from G-protein-coupled receptors (GPCRs) to intracellular effectors. GNAI1 inhibits adenylyl cyclase, leading to decreased cyclic AMP (cAMP) production and downstream signaling. This negatively regulates cellular processes such as neurotransmission, hormone secretion, and cell growth. GNAI1 is involved in various physiological functions, including the modulation of cardiovascular responses, neuronal activity, and immune cell function. Dysregulation of GNAI1 has been associated with several diseases, emphasizing its importance as a signaling molecule and a potential therapeutic target in various disorders.
| Cat.No | ACP01072 | Target Name | GNAI1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-354aa | Mol Weight | 47.7 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P63096 |
|---|
Uniprot Id
P63096
Target Species
Human
Target Name
GNAI1
Target Full Name
Guanine nucleotide-binding protein G(i) subunit alpha-1
Target Function
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis. Required for cortical dynein-dynactin complex recruitment during metaphase.
Target Subcellular Location
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex. Membrane; Lipid-anchor.
Target Protein Families
G-alpha family, G(i/o/t/z) subfamily
Target Research Area
Signal Transduction
Target Synonyms
Adenylate cyclase inhibiting G alpha protein; Adenylate cyclase inhibitory protein; Adenylate cyclase-inhibiting G alpha protein; G protein alpha inhibiting 1; G protein alpha inhibiting activity polypeptide 1; Gi; Gi inhibitory G protein; Gi1 protein alpha subunit; GNAI 1; GNAI1; GNAI1_HUMAN; Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 1; Guanine nucleotide binding protein G(i) alpha 1 subunit; Guanine nucleotide-binding protein G(i) subunit alpha-1; OTTHUMP00000161319; OTTHUMP00000208047
Target Background
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
