Recombinant Human Guanine nucleotide-binding protein subunit alpha-11 (GNA11)

Uniprot Id

P29992

Target Species

Human

Target Name

GNA11

Target Full Name

Guanine nucleotide-binding protein subunit alpha-11

Target Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).

Target Involvement

Hypocalciuric hypercalcemia, familial 2 (HHC2); Hypocalcemia, autosomal dominant 2 (HYPOC2)

Target Subcellular Location

Cell membrane; Lipid-anchor. Cytoplasm. Note=In testicular cells, expressed exclusively in the cytoplasm.

Target Protein Families

G-alpha family, G(q) subfamily

Target Tissue Specificity

Expressed in testis.

Target Synonyms

G alpha-11; G-protein subunit alpha-11; GA11; GNA11; GNA11_HUMAN; guanine nucleotide binding protein (G protein); alpha 11 (Gq class); Guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11; guanine nucleotide-binding protein; alpha 11; guanine nucleotide-binding protein; Gq class; GNA11

Target Background

The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations.