Recombinant Human Haptoglobin (HP)

The region for expressing recombinant Human HP (Haptoglobin) contains amino acids 19-406. The expected molecular weight for the HP (Haptoglobin) protein is calculated to be 57.3 kDa. The HP (Haptoglobin) protein was expressed in e.coli. The HP (Haptoglobin) gene fragment has been modified by fusing the N-terminal 6xHis-B2M tag, providing convenience in detecting and purifying the recombinant HP (Haptoglobin) protein during the following stages.Human haptoglobin (HP) is a glycoprotein primarily synthesized by the liver and released into the bloodstream. Haptoglobin mainly binds to free hemoglobin, released during the breakdown of red blood cells, preventing oxidative damage and facilitating its clearance by macrophages. This haptoglobin-hemoglobin complex is then efficiently removed from circulation, preventing the harmful effects of free hemoglobin. Beyond its role in hemoglobin scavenging, haptoglobin is involved in immunomodulation and inflammation, influencing processes like the acute-phase response. Additionally, genetic variations in haptoglobin exist, contributing to individual differences in susceptibility to certain diseases. Research on haptoglobin spans various medical fields, including hematology, immunology, and genetics, exploring its multifaceted functions and clinical relevance.

ACP02658

Number

Cat.No	ACP02658	Target Name	HP
Target Synonyms	alpha polypeptide; Haptoglobin, beta polypeptide; HP; HP2 ALPHA2; HP2ALPHA2; HPA1S; HPT; HPT_HUMAN; MGC111141; Zonulin, Binding peptide; BP; Haptoglobin alpha chain; Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta; Haptoglobin beta chain; Haptoglobin	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	19-406aa
Mol Weight	57.3 kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02658

Target Name

Target Synonyms

alpha polypeptide; Haptoglobin, beta polypeptide; HP; HP2 ALPHA2; HP2ALPHA2; HPA1S; HPT; HPT_HUMAN; MGC111141; Zonulin, Binding peptide; BP; Haptoglobin alpha chain; Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta; Haptoglobin beta chain; Haptoglobin

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

19-406aa

Mol Weight

57.3 kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P00738

Background Information

Uniprot Id

P00738
Target Species

Human
Target Name

HP
Target Full Name

Haptoglobin
Target Function

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.; The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
Target Involvement

Anhaptoglobinemia (AHP)
Target Subcellular Location

Secreted.
Target Protein Families

Peptidase S1 family
Target Tissue Specificity

Expressed by the liver and secreted in plasma.
Target Research Area

Immunology, Cardiovascular
Target Synonyms

Binding peptide; BP; Haptoglobin alpha chain; Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta; Haptoglobin beta chain; Haptoglobin, alpha polypeptide; Haptoglobin, beta polypeptide; HP; HP2 ALPHA2; HP2ALPHA2; HPA1S; HPT; HPT_HUMAN; MGC111141; Zonulin
Target Background

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Haptoglobin (HP)

Specifications

Immunogen Information

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