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Amino acids 1-1003 constitute the expression domain of recombinant Human MOV10. The theoretical molecular weight of the MOV10 protein is 119.6 kDa. This MOV10 protein is produced using e.coli expression system. The MOV10 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant MOV10 protein in following stages of expression and purification.The human helicase MOV10 is a member of the UPF1-like RNA helicase family. MOV10 is involved in various cellular processes, including RNA metabolism and innate immunity. It plays a crucial role in RNA interference (RNAi) and RNA silencing pathways by unwinding RNA duplexes and facilitating the processing of small RNAs. MOV10 is also implicated in mRNA translation regulation, RNA editing, and retroviral restriction. Additionally, it has been associated with RNA-induced silencing complex (RISC) assembly and the control of endogenous retroelement expression. The multifaceted functions of MOV10 highlight its significance in maintaining RNA homeostasis and host defense mechanisms.
Amino acids 1-1003 constitute the expression domain of recombinant Human MOV10. The theoretical molecular weight of the MOV10 protein is 119.6 kDa. This MOV10 protein is produced using e.coli expression system. The MOV10 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant MOV10 protein in following stages of expression and purification.The human helicase MOV10 is a member of the UPF1-like RNA helicase family. MOV10 is involved in various cellular processes, including RNA metabolism and innate immunity. It plays a crucial role in RNA interference (RNAi) and RNA silencing pathways by unwinding RNA duplexes and facilitating the processing of small RNAs. MOV10 is also implicated in mRNA translation regulation, RNA editing, and retroviral restriction. Additionally, it has been associated with RNA-induced silencing complex (RISC) assembly and the control of endogenous retroelement expression. The multifaceted functions of MOV10 highlight its significance in maintaining RNA homeostasis and host defense mechanisms.
| Cat.No | ACP00986 | Target Name | MOV10 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-1003aa | Mol Weight | 119.6 kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HCE1 |
|---|
Uniprot Id
Q9HCE1
Target Species
Human
Target Name
MOV10
Target Full Name
Helicase MOV-10
Target Function
5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7. Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor. Exhibits antiviral activity against dengue virus (DENV).; (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.
Target Subcellular Location
Cytoplasm, P-body. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, Stress granule. Nucleus. Cytoplasm.
Target Protein Families
DNA2/NAM7 helicase family, SDE3 subfamily
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
MOV10; KIAA1631; Helicase MOV-10; EC 3.6.4.13; Armitage homolog; Moloney leukemia virus 10 protein
Target Background
Enables 5'-3' RNA helicase activity and RNA binding activity. Involved in defense response to virus; negative regulation of transposition, RNA-mediated; and posttranscriptional regulation of gene expression. Located in P-body and cytosol. Implicated in hypertension.
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