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Recombinant Human Hematological and neurological expressed 1 protein (HN1)

ACP08797

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Specifications

Cat.No	ACP08797	Target Name	JPT1
Target Synonyms	Androgen regulated protein 2; Androgen-regulated protein 2; ARM2; Hematological and neurological expressed 1; Hematological and neurological expressed 1 protein; HN1; HN1_HUMAN; HN1A	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	2-154aa
Mol Weight	31.9kD	Protein Length	Hematological and neurological expressed 1 protein, N-terminally processed
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9UK76

Background Information

Uniprot Id

Q9UK76
Target Species

Human
Target Name

JPT1
Target Full Name

Jupiter microtubule associated homolog 1
Target Function

Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.
Target Subcellular Location

Nucleus. Cytoplasm.
Target Protein Families

JUPITER family
Target Tissue Specificity

Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

Androgen regulated protein 2; Androgen-regulated protein 2; ARM2; Hematological and neurological expressed 1; Hematological and neurological expressed 1 protein; HN1; HN1_HUMAN; HN1A
Target Background

Located in nuclear membrane; nucleolus; and nucleoplasm.

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Recombinant Human Hematological and neurological expressed 1 protein (HN1)

Specifications

Immunogen Information

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