Recombinant Human Hepatitis A virus cellular receptor 1 (HAVCR1), Truncated

To express the recombinant Human HAVCR1 protein in mammalian cells, a DNA fragment encoding the Human HAVCR1 protein (21-290aa) is inserted into a plasmid vector and transferred to the mammalian cells. Cells containing the plasmid are screened, cultured, and induced to express the HAVCR1 protein. The protein carries a C-terminal hFc-Myc tag. Lysing the cells allows for the collection of the recombinant Human HAVCR1 protein, which is purified through affinity purification and then identified through SDS-PAGE and subsequent staining of the gel with Coomassie Brilliant Blue. The purity of the recombinant Human HAVCR1 protein obtained is greater than 85%.

ACP04977

Number

Cat.No	ACP04977	Target Name	HAVCR1
Form	Liquid or Lyophilized powder	Expression System	Mammalian cell
Expression Range	21-290aa	Mol Weight	59.1
Protein Length	Partial	Purity	Greater than 85% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04977

Target Name

HAVCR1

Form

Liquid or Lyophilized powder

Expression System

Mammalian cell

Expression Range

21-290aa

Mol Weight

59.1

Protein Length

Partial

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96D42

Background Information

Uniprot Id

Q96D42
Target Species

Human
Target Name

HAVCR1
Target Full Name

Hepatitis A virus cellular receptor 1
Target Function

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair.; (Microbial infection) Acts as a receptor for Hepatitis A virus.; (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane. Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP.; (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane.; (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E.
Target Subcellular Location

Membrane; Single-pass type I membrane protein.
Target Protein Families

Immunoglobulin superfamily, TIM family
Target Tissue Specificity

Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.
Target Research Area

Immunology
Target Synonyms

CD365; HAVCR 1 ; HAVCR; HAVcr-1; Havcr1; Hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM 1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; T cell immunoglobulin mucin family member 1; T cell immunoglobulin mucin receptor 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell membrane protein 1; TIM; TIM-1; TIM1; TIMD 1; TIMD-1; TIMD1; TIMD1_HUMAN
Target Background

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple other viruses, including Ebola virus, Marburg virus, Dengue virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and other coronaviruses.

Recombinant Human Hepatitis A virus cellular receptor 1 (HAVCR1), Truncated

Specifications

Immunogen Information

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