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The region for expressing recombinant Human HNF4A contains amino acids 1-474. The theoretical molecular weight of the HNF4A protein is 59.8 kDa. This protein is generated in a e.coli-based system. The HNF4A gene fragment has been modified by fusing the N-terminal 10xHis tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant HNF4A protein during the following stages.Human hepatocyte nuclear factor 4-alpha (HNF4A) is a transcription factor that plays a crucial role in the development and function of various organs, with a predominant presence in the liver, kidney, and intestine. As a member of the nuclear receptor superfamily, HNF4A regulates the expression of genes involved in glucose and lipid metabolism, as well as cell differentiation and proliferation. It is a key player in maintaining liver function, controlling the balance of glucose and lipid homeostasis, and influencing the development of pancreatic beta cells. Mutations in the HNF4A gene are associated with maturity-onset diabetes of the young (MODY), underlining its significance in insulin secretion. Research on HNF4A extends to understanding its role in metabolic disorders, organ development, and potential therapeutic targets for diabetes and related conditions.
The region for expressing recombinant Human HNF4A contains amino acids 1-474. The theoretical molecular weight of the HNF4A protein is 59.8 kDa. This protein is generated in a e.coli-based system. The HNF4A gene fragment has been modified by fusing the N-terminal 10xHis tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant HNF4A protein during the following stages.Human hepatocyte nuclear factor 4-alpha (HNF4A) is a transcription factor that plays a crucial role in the development and function of various organs, with a predominant presence in the liver, kidney, and intestine. As a member of the nuclear receptor superfamily, HNF4A regulates the expression of genes involved in glucose and lipid metabolism, as well as cell differentiation and proliferation. It is a key player in maintaining liver function, controlling the balance of glucose and lipid homeostasis, and influencing the development of pancreatic beta cells. Mutations in the HNF4A gene are associated with maturity-onset diabetes of the young (MODY), underlining its significance in insulin secretion. Research on HNF4A extends to understanding its role in metabolic disorders, organ development, and potential therapeutic targets for diabetes and related conditions.
| Cat.No | ACP05219 | Target Name | HNF4A |
|---|---|---|---|
| Target Synonyms | hepatic nuclear factor; Transcription factor 14; Transcription factor HNF 4; Transcription factor HNF-4; Transcription factor HNF4 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-474aa |
| Mol Weight | 59.8 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P41235 |
|---|
Uniprot Id
P41235
Target Species
Human
Target Name
HNF4A
Target Full Name
Hepatocyte nuclear factor 4-alpha
Target Function
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes. Activates the transcription of CYP2C38. Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells.
Target Involvement
Maturity-onset diabetes of the young 1 (MODY1); Diabetes mellitus, non-insulin-dependent (NIDDM); Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young (FRTS4)
Target Subcellular Location
Nucleus.
Target Protein Families
Nuclear hormone receptor family, NR2 subfamily
Target Research Area
Cancer
Target Synonyms
FLJ39654; FRTS4; Hepatic nuclear factor 4 alpha; Hepatocyte nuclear factor 4 alpha; Hepatocyte nuclear factor 4; Hepatocyte nuclear factor 4-alpha; HNF 4 alpha; HNF 4; HNF-4-alpha; HNF4 ; HNF4A; HNF4A_HUMAN; HNF4a7; HNF4a8; HNF4a9; Hnf4alpha; HNF4alpha10/11/12; MODY 1; MODY; MODY1; NR2A1 ; NR2A21; Nuclear receptor subfamily 2 group A member 1; OTTHUMP00000031060; OTTHUMP00000031062; TCF 14; TCF; TCF-14; TCF14 ; Tcf4; Transcription factor 14, hepatic nuclear factor; Transcription factor 14; Transcription factor HNF 4; Transcription factor HNF-4; Transcription factor HNF4
Target Background
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
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