Recombinant Human Hepatocyte nuclear factor 6 (ONECUT1)

Uniprot Id

Q9UBC0

Target Species

Human

Target Name

ONECUT1

Target Full Name

Hepatocyte nuclear factor 6

Target Function

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

Target Subcellular Location

Nucleus.

Target Protein Families

CUT homeobox family

Target Tissue Specificity

Highly expressed in liver; lower expression in testis and skin.

Target Synonyms

hepatocyte nuclear factor 6 alpha; Hepatocyte nuclear factor 6; HNF 6; HNF-6; HNF6_HUMAN; HNF6A; One cut domain family member 1; One cut homeobox 1; Onecut1

Target Background

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.