Recombinant Human Hepcidin (HAMP), Truncated

Uniprot Id

P81172

Target Species

Human

Target Name

HAMP

Target Full Name

Hepcidin

Target Function

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.; Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.

Target Involvement

Hemochromatosis 2B (HFE2B)

Target Subcellular Location

Secreted.

Target Protein Families

Hepcidin family

Target Tissue Specificity

Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine and blood. Expressed by hepatocytes.

Target Research Area

Signal Transduction

Target Synonyms

Hamp; HEPC; HEPC_HUMAN; Hepc20; Hepc25; HEPCIDIN ; Hepcidin 20; Hepcidin 25; Hepcidin antimicrobial peptide ; Hepcidin-20; Hepcidin25; HFE2; HFE2B; LEAP 1; LEAP-1; LEAP1; Liver expressed antimicrobial peptide; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor