Recombinant Human HERV-K_6q14.1 provirus ancestral Env polyprotein, Truncated

Uniprot Id

Q9UKH3

Target Species

Human

Target Name

ERVK-9

Target Full Name

Endogenous retrovirus group K member 9 Env polyprotein

Target Function

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.; SU mediates receptor recognition.; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.

Target Subcellular Location

[Transmembrane protein]: Cell membrane; Single-pass type I membrane protein.; [Surface protein]: Cell membrane; Peripheral membrane protein.; [Endogenous retrovirus group K member 9 Env polyprotein]: Virion.

Target Protein Families

Beta type-B retroviral envelope protein family, HERV class-II K(HML-2) env subfamily

Target Synonyms

ERVK-9Endogenous retrovirus group K member 9 Env polyprotein; EnvK4 protein; Envelope polyprotein; HERV-K(C6) envelope protein; HERV-K109 envelope protein; HERV-K_6q14.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein; SU); Transmembrane protein; TM)]