Recombinant Human Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)

The region for expressing recombinant Human HNRNPH1 contains amino acids 2-449. This HNRNPH1 protein is theoretically predicted to have a molecular weight of 65.1 kDa. This HNRNPH1 recombinant protein is manufactured in e.coli. The HNRNPH1 gene fragment has been modified by fusing the N-terminal 6xHis-SUMO tag, providing convenience in detecting and purifying the recombinant HNRNPH1 protein during the following stages.Human heterogeneous nuclear ribonucleoprotein H (HNRNPH1) is a multifunctional RNA-binding protein that plays crucial roles in various aspects of RNA metabolism. As a member of the hnRNP family, HNRNPH1 is involved in pre-mRNA processing, including splicing, mRNA transport, and stability. It forms ribonucleoprotein complexes and contributes to the regulation of alternative splicing, influencing the diversity of the proteome. Beyond its role in RNA processing, HNRNPH1 has been implicated in other cellular functions, including transcriptional regulation and telomere maintenance. Dysregulation of HNRNPH1 has been associated with several diseases, including cancer, highlighting its significance in cellular homeostasis.

ACP04057

Number

Cat.No	ACP04057	Target Name	HNRNPH1
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	2-449aa	Mol Weight	65.1kDa
Protein Length	Full Length of Mature Protein	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04057

Target Name

HNRNPH1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

2-449aa

Mol Weight

65.1kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P31943

Background Information

Uniprot Id

P31943
Target Species

Human
Target Name

HNRNPH1
Target Full Name

Heterogeneous nuclear ribonucleoprotein H
Target Function

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).
Target Subcellular Location

Nucleus, nucleoplasm.
Target Tissue Specificity

Expressed ubiquitously.
Target Research Area

Transcription
Target Synonyms

DKFZp686A15170; Heterogeneous nuclear ribonucleoprotein H; Heterogeneous nuclear ribonucleoprotein H1 (H); Heterogeneous nuclear ribonucleoprotein H1; HNRH1_HUMAN; hnRNP H; hnRNPH; Hnrnph1; HNRPH 1; HNRPH; HNRPH1 protein; N-terminally processed
Target Background

This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described

Recombinant Human Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)

Specifications

Immunogen Information

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