Recombinant Human Hexokinase-2 (HK2), Truncated

Uniprot Id

P52789

Target Species

Human

Target Name

HK2

Target Full Name

Hexokinase-2

Target Function

Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.

Target Subcellular Location

Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol.

Target Protein Families

Hexokinase family

Target Tissue Specificity

Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.

Target Synonyms

DKFZp686M1669; Hexokinase 2; Hexokinase 2 muscle; Hexokinase type II; Hexokinase-2; HK 2; HK II; HK2; HKII; HxK 2; HxK2; HXK2_HUMAN; Muscle form hexokinase

Target Background

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.