Recombinant Human Histone chaperone ASF1B (ASF1B)

Uniprot Id

Q9NVP2

Target Species

Human

Target Name

ASF1B

Target Full Name

Histone chaperone ASF1B

Target Function

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.

Target Subcellular Location

Nucleus.

Target Protein Families

ASF1 family

Target Tissue Specificity

Highly expressed in testis and at lower levels in colon, small intestine and thymus.

Target Synonyms

Anti silencing function 1B; Anti silencing function 1B histone chaperone; Anti-silencing function protein 1 homolog B; ASF1 anti silencing function 1 homolog B (S. cerevisiae); ASF1 anti silencing function 1 homolog B; ASF1B; ASF1B_HUMAN; CCG1 interacting factor A II; CCG1-interacting factor A-II; CIA-II; hAsf1; hAsf1b; hCIA-II; Histone chaperone ASF1B

Target Background

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.