Recombinant Human Homeobox protein Nkx-3.2 (Nkx3-2)

Uniprot Id

P78367

Target Species

Human

Target Name

NKX3-2

Target Full Name

Homeobox protein Nkx-3.2

Target Function

Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.

Target Involvement

Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD)

Target Subcellular Location

Nucleus.

Target Protein Families

NK-3 homeobox family

Target Tissue Specificity

Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

Bagpipe homeobox 1; Bagpipe homeobox homolog 1; Bagpipe homeobox protein homolog 1; Bagpipe homeobox; Drosophila; homolog of; 1; BAPX 1; Homeobox protein NK-3 homolog B; Homeobox protein Nkx 3.2; Homeobox protein Nkx-3.2; MGC138171; NK3 homeobox 2; NKX3 2; NKX3-2; NKX3.2; NKX3.2; mouse; homolog of; NKX32_HUMAN; NKX3B; OTTHUMP00000115816; SMMD

Target Background

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation; negative regulation of chondrocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including animal organ development; embryonic skeletal system development; and intestinal epithelial cell development. Predicted to be part of chromatin. Predicted to be active in nucleus.