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Recombinant Human Homer protein homolog 3 (HOMER3)

ACP11192

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Specifications

Cat.No	ACP11192	Target Name	HOMER3
Target Synonyms	HOME3_HUMAN; HOMER 3; Homer 3D protein ; Homer homolog 3 (Drosophila); Homer neuronal immediate early gene 3; Homer protein homolog 3; Homer-3; Homer3; VESL3	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-361
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9NSC5

Background Information

Uniprot Id

Q9NSC5
Target Species

Human
Target Name

HOMER3
Target Full Name

Homer protein homolog 3
Target Function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Target Subcellular Location

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
Target Protein Families

Homer family
Target Synonyms

HOME3_HUMAN; HOMER 3; Homer 3D protein ; Homer homolog 3 (Drosophila); Homer neuronal immediate early gene 3; Homer protein homolog 3; Homer-3; Homer3; VESL3

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Recombinant Human Homer protein homolog 3 (HOMER3)

Specifications

Immunogen Information

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