Recombinant Human Huntingtin-interacting protein 1-related protein (HIP1R), Truncated

Uniprot Id

O75146

Target Species

Human

Target Name

HIP1R

Target Full Name

Huntingtin-interacting protein 1-related protein

Target Function

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.

Target Subcellular Location

Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.

Target Protein Families

SLA2 family

Target Tissue Specificity

Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.

Target Synonyms

FLJ14000; FLJ27022; HIP-12; Hip1 related ; HIP1-related protein; HIP12; HIP1R; HIP1R_HUMAN; HIP3; Huntingtin Interacting Protein 1 Related; Huntingtin interacting protein 12; Huntingtin-interacting protein 1-related protein; Huntingtin-interacting protein 12; ILWEQ; KIAA0655; MGC47513

Target Background

Enables several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3, 4-bisphosphate binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of signal transduction; protein stabilization; and regulation of organelle organization. Located in clathrin-coated vesicle; cytosol; and ruffle membrane.