Recombinant Human Hyaluronidase-1 (HYAL1), Truncated

Uniprot Id

Q12794

Target Species

Human

Target Name

HYAL1

Target Full Name

Hyaluronidase-1

Target Function

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

Target Involvement

Mucopolysaccharidosis 9 (MPS9)

Target Subcellular Location

Secreted. Lysosome.

Target Protein Families

Glycosyl hydrolase 56 family

Target Tissue Specificity

Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node sp

Target Research Area

Cancer

Target Synonyms

HYAL 1; Hyal-1; HYAL1; HYAL1_HUMAN; Hyaluronidase 1; Hyaluronidase-1; Hyaluronoglucosaminidase 1; Hyaluronoglucosaminidase-1; Hyaluronoglucosaminidase1; LUCA 1; LUCA-1; LUCA1; Lung carcinoma protein 1; MGC45987; NAT6; Plasma hyaluronidase; Tumor suppressor LUCA 1

Target Background

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.