Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT), Truncated

Cat.No	ACP03683	Target Name	FCGRT
Form	Liquid or Lyophilized powder	Expression System	Yeast
Expression Range	24-297aa	Mol Weight	32.4kDa
Protein Length	Extracellular Domain	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03683

Target Name

FCGRT

Form

Liquid or Lyophilized powder

Expression System

Yeast

Expression Range

24-297aa

Mol Weight

32.4kDa

Protein Length

Extracellular Domain

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P55899

Background Information

Uniprot Id

P55899
Target Species

Human
Target Name

FCGRT
Target Full Name

IgG receptor FcRn large subunit p51
Target Function

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.; (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endosome membrane.
Target Protein Families

Immunoglobulin superfamily
Target Tissue Specificity

Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.
Target Research Area

Immunology
Target Synonyms

Alpha chain; Fc fragment of IgG; receptor transporter; alpha; FCGRN_HUMAN; FCGRT; FcRn alpha chain; FcRn; FCRN; alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor; intestinal; heavy chain; Neonatal Fc receptor
Target Background

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.

Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT), Truncated Now

Related Products