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The synthesis of this Recombinant Human PTK7 protein depends on the utilization of recombinant DNA technology to a large degree. DNA sequences that encoded the PTK7 protein could be inserted into a vector and introduced into an expression host, Yeast, where it could be easily expressed in and purified from. The expression of this PTK7 protein was at 31-704aa. N-terminal 6xHis tag was fused with this protein. The purity is 90%+ determined by SDS-PAGE. PTK7 (also known as CCK4) is gene encoding a protein named inactive tyrosine-protein kinase 7(PTK7) in human. The protein encoded by this gene is also known as colon carcinoma kinase 4 (CCK4), protein-tyrosine kinase 7, pseudo tyrosine kinase receptor 7 and tyrosine-protein kinase-like 7. The protein encoded by this gene is a positive regulator of canonical Wnt signaling pathway with its coreceptor activity. Moreover, this protein is also involved other biological processes, such as actin cytoskeleton reorganization, cell adhesion, cell migration and signal transduction.
The synthesis of this Recombinant Human PTK7 protein depends on the utilization of recombinant DNA technology to a large degree. DNA sequences that encoded the PTK7 protein could be inserted into a vector and introduced into an expression host, Yeast, where it could be easily expressed in and purified from. The expression of this PTK7 protein was at 31-704aa. N-terminal 6xHis tag was fused with this protein. The purity is 90%+ determined by SDS-PAGE.
PTK7 (also known as CCK4) is gene encoding a protein named inactive tyrosine-protein kinase 7(PTK7) in human. The protein encoded by this gene is also known as colon carcinoma kinase 4 (CCK4), protein-tyrosine kinase 7, pseudo tyrosine kinase receptor 7 and tyrosine-protein kinase-like 7. The protein encoded by this gene is a positive regulator of canonical Wnt signaling pathway with its coreceptor activity. Moreover, this protein is also involved other biological processes, such as actin cytoskeleton reorganization, cell adhesion, cell migration and signal transduction.
| Cat.No | ACP02536 | Target Name | PTK7 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Yeast |
| Expression Range | 31-704aa | Mol Weight | 76.6kDa |
| Protein Length | Extracellular Domain | Purity | Greater than 90% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13308 |
|---|
Uniprot Id
Q13308
Target Species
Human
Target Name
PTK7
Target Full Name
Inactive tyrosine-protein kinase 7
Target Function
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Target Subcellular Location
Membrane; Single-pass type I membrane protein. Cell junction. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
Target Protein Families
Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Target Tissue Specificity
Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
Target Research Area
Cell Adhesion
Target Synonyms
8430404F20Rik; CCK 4; CCK-4; Colon carcinoma kinase 4; Human colon carcinoma kinase 4 (CCK4) mRNA complete cds; Inactive tyrosine-protein kinase 7; mPTK7/CCK4; OTTHUMP00000217016; Protein tyrosine kinase PTK 7; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK 7; PTK7; PTK7 protein tyrosine kinase 7; PTK7 protein tyrosine kinase; PTK7_HUMAN; Serum response factor; Srf; Tyrosine-protein kinase-like 7
Target Background
This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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