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| Cat.No | ACP23668 | Target Name | IGFALS |
|---|---|---|---|
| Target Synonyms | IGFALS; ALSInsulin-like growth factor-binding protein complex acid labile subunit; ALS | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 28-605 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P35858 |
|---|
Uniprot Id
P35858
Target Species
Human
Target Name
IGFALS
Target Full Name
Insulin-like growth factor-binding protein complex acid labile subunit
Target Function
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
Target Involvement
Acid-labile subunit deficiency (ACLSD)
Target Subcellular Location
Secreted, extracellular space.
Target Tissue Specificity
Plasma.
Target Synonyms
IGFALS; ALSInsulin-like growth factor-binding protein complex acid labile subunit; ALS
Target Background
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.
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