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Boost your signal transduction research with our premium-quality Recombinant Human IGF1 protein, a vital growth factor that mediates cell growth, differentiation, and metabolism. As a key player in the regulation of cell physiology, IGF1 is involved in numerous biological processes and implicated in various pathological conditions, such as cancer, diabetes, and aging. Our Recombinant Human IGF1 protein features the full-length mature sequence (49-118 amino acids) and is expressed in E. coli to maintain high-level protein yield and bioactivity. The N-terminal GST-tag enhances purification and detection while maintaining the protein's native structure and function. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human IGF1 protein guarantees accurate and reliable results in your experiments. Available in both liquid and lyophilized powder forms, this versatile protein is ready to support your research needs.
Boost your signal transduction research with our premium-quality Recombinant Human IGF1 protein, a vital growth factor that mediates cell growth, differentiation, and metabolism. As a key player in the regulation of cell physiology, IGF1 is involved in numerous biological processes and implicated in various pathological conditions, such as cancer, diabetes, and aging.
Our Recombinant Human IGF1 protein features the full-length mature sequence (49-118 amino acids) and is expressed in E. coli to maintain high-level protein yield and bioactivity. The N-terminal GST-tag enhances purification and detection while maintaining the protein’s native structure and function. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human IGF1 protein guarantees accurate and reliable results in your experiments. Available in both liquid and lyophilized powder forms, this versatile protein is ready to support your research needs.
| Cat.No | ACP02292 | Target Name | IGF1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 49-118aa | Mol Weight | 34.7kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P05019 |
|---|
Uniprot Id
P05019
Target Species
Human
Target Name
IGF1
Target Full Name
Insulin-like growth factor 1
Target Function
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.
Target Involvement
Insulin-like growth factor I deficiency (IGF1 deficiency)
Target Subcellular Location
Secreted.
Target Protein Families
Insulin family
Target Research Area
Signal Transduction
Target Synonyms
IBP1; IGF I; IGF IA; IGF IB; IGF-I; Igf1; IGF1_HUMAN; IGF1A; IGFI; IGFIA; Insulin like growth factor 1 (somatomedin C) ; Insulin like growth factor 1; Insulin like growth factor IA; Insulin like growth factor IB; Insulin-like growth factor I; Mechano growth factor; MGF; OTTHUMP00000195080; OTTHUMP00000195081; OTTHUMP00000195082; OTTHUMP00000195083; OTTHUMP00000195084; Somatomedia C; Somatomedin C; Somatomedin-C
Target Background
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.
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