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| Cat.No | ACP06637 | Target Name | GPR137B |
|---|---|---|---|
| Target Synonyms | GPR137B; TM7SF1; Integral membrane protein GPR137B; Transmembrane 7 superfamily member 1 protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O60478 |
|---|
Uniprot Id
O60478
Target Species
Human
Target Name
GPR137B
Target Full Name
Integral membrane protein GPR137B
Target Function
Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy.; Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polarization.
Target Subcellular Location
Lysosome membrane; Multi-pass membrane protein.
Target Protein Families
GPR137 family
Target Tissue Specificity
Expressed in kidney, heart, brain and placenta.
Target Synonyms
GPR137B; TM7SF1; Integral membrane protein GPR137B; Transmembrane 7 superfamily member 1 protein
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