Recombinant Human Integrator complex subunit 5 (INTS5), Truncated

Uniprot Id

Q6P9B9

Target Species

Human

Target Name

INTS5

Target Full Name

Integrator complex subunit 5

Target Function

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.

Target Subcellular Location

Nucleus membrane; Multi-pass membrane protein. Nucleus. Cytoplasm.

Target Protein Families

Integrator subunit 5 family

Target Synonyms

INTS5; KIAA1698; Integrator complex subunit 5; Int5

Target Background

The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex.