Recombinant Human Integrator complex subunit 6 (INTS6), Truncated

Uniprot Id

Q9UL03

Target Species

Human

Target Name

INTS6

Target Full Name

Integrator complex subunit 6

Target Function

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.

Target Subcellular Location

Nucleus.

Target Protein Families

Integrator subunit 6 family

Target Tissue Specificity

Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Target Synonyms

DBI 1; DBI-1; DBI1; DDX26; DDX26A; DEAD box protein; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 26; Deleted in cancer 1; DICE1; DKFZp434B105; HDB; Int6; INT6_HUMAN; Integrator complex subunit 6; INTS 6; ints6; Notchl2; OTTHUMP00000018439; OTTHUMP00000215034; OTTHUMP00000215036; Protein DDX26; Protein deleted in cancer 1; RNA helicase HDB

Target Background

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene.