Recombinant Human Integrin alpha-E (ITGAE), Truncated

Uniprot Id

P38570

Target Species

Human

Target Name

ITGAE

Target Full Name

Integrin alpha-E

Target Function

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Integrin alpha chain family

Target Tissue Specificity

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Target Synonyms

A530055J10; alpha-E1; alpha-M290; aM290; Antigen CD103; CD 103; CD103; CD103 antigen; HML 1 antigen; HML-1 antigen; HML1 antigen; Human mucosal lymphocyte antigen 1; Human mucosal lymphocyte antigen 1, alpha subunit; Huminae; Integrin alpha E; Integrin alpha E heavy chain; Integrin alpha E light chain; Integrin alpha E, epithelial-associated; Integrin alpha E1 ; Integrin alpha IEL ; Integrin alpha M290; Integrin alpha-E heavy chain; Integrin alpha-IEL; Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1, alpha polypeptide); Integrin, alpha E; ITAE_HUMAN; Itgae; MGC141996; MGC183601; Mucosal lymphocyte 1 antigen; Mucosal lymphocyte antigen 1

Target Background

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.