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| Cat.No | ACP14738 | Target Name | ITFG2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-447 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q969R8 |
|---|
Uniprot Id
Q969R8
Target Species
Human
Target Name
ITFG2
Target Full Name
KICSTOR complex protein ITFG2
Target Function
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Target Subcellular Location
Lysosome membrane.
Target Synonyms
Integrin alpha FG GAP repeat containing 2; Integrin alpha FG GAP repeat containing protein 2; Integrin-alpha FG-GAP repeat-containing protein 2; ITFG 2; ITFG2; ITFG2_HUMAN; MDS 028; MDS028; OTTHUMP00000161190; RGD1311944; Uncharacterized hematopoietic stem/progenitor cells protein MDS028
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