Recombinant Human Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)

Uniprot Id

P19827

Target Species

Human

Target Name

ITIH1

Target Full Name

Inter-alpha-trypsin inhibitor heavy chain H1

Target Function

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.; Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.

Target Subcellular Location

Secreted.

Target Protein Families

ITIH family

Target Synonyms

H1P; IATIH; IGHEP1; Inter alpha (globulin) inhibitor H1; Inter alpha (globulin) inhibitor H1 polypeptide; Inter alpha trypsin inhibitor heavy chain 1; Inter alpha trypsin inhibitor heavy chain H1; Inter-alpha-inhibitor heavy chain 1; Inter-alpha-trypsin inhibitor complex component III; Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; ITI-HC1; ITIH; ITIH1; ITIH1_HUMAN; Serum-derived hyaluronan-associated protein; SHAP

Target Background

This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3.