Recombinant Human Interleukin-21 receptor (IL21R), Truncated

Uniprot Id

Q9HBE5

Target Species

Human

Target Name

IL21R

Target Full Name

Interleukin-21 receptor

Target Function

This is a receptor for interleukin-21.

Target Involvement

IL21R immunodeficiency (IL21RID)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Type I cytokine receptor family, Type 4 subfamily

Target Tissue Specificity

Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.

Target Synonyms

CD360; IL 21R; IL-21 receptor; IL-21R; IL21 receptor; IL21R; IL21R_HUMAN; Interleukin 21 receptor; Interleukin-21 receptor; MGC10967; NILR; Novel interleukin receptor

Target Background

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.