Recombinant Human Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU)

Unleash the power of our Recombinant Human ISCU protein in your signal transduction research, and explore its role in the vital process of iron-sulfur cluster biogenesis. ISCU, the Iron-sulfur cluster assembly enzyme, is a critical component in the assembly and transfer of Fe-S clusters, which serve as essential cofactors for a multitude of cellular processes, including electron transfer and enzyme catalysis. Our Recombinant Human ISCU protein offers a full-length sequence (1-167 amino acids) for optimal functionality and bioactivity. Produced in E. coli, this protein features an N-terminal GST-tag, facilitating efficient purification and detection without affecting the protein's native structure or biological activity. With a purity of greater than 90% as determined by SDS-PAGE, our Recombinant Human ISCU protein guarantees consistent and reliable results, providing a dependable tool for your research endeavors. Choose from liquid or lyophilized powder forms to best suit your experimental needs.

ACP03159

Unleash the power of our Recombinant Human ISCU protein in your signal transduction research, and explore its role in the vital process of iron-sulfur cluster biogenesis. ISCU, the Iron-sulfur cluster assembly enzyme, is a critical component in the assembly and transfer of Fe-S clusters, which serve as essential cofactors for a multitude of cellular processes, including electron transfer and enzyme catalysis.
Our Recombinant Human ISCU protein offers a full-length sequence (1-167 amino acids) for optimal functionality and bioactivity. Produced in E. coli, this protein features an N-terminal GST-tag, facilitating efficient purification and detection without affecting the protein’s native structure or biological activity. With a purity of greater than 90% as determined by SDS-PAGE, our Recombinant Human ISCU protein guarantees consistent and reliable results, providing a dependable tool for your research endeavors. Choose from liquid or lyophilized powder forms to best suit your experimental needs.

Number

Cat.No	ACP03159	Target Name	ISCU
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-167aa	Mol Weight	45.0kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03159

Target Name

ISCU

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-167aa

Mol Weight

45.0kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9H1K1

Background Information

Uniprot Id

Q9H1K1
Target Species

Human
Target Name

ISCU
Target Full Name

Iron-sulfur cluster assembly enzyme ISCU
Target Function

Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic Functions as a cytoplasmic scaffold protein for the de novo synthesis of iron-sulfur clusters in the cytoplasm.
Target Involvement

Myopathy with exercise intolerance Swedish type (MEIS)
Target Subcellular Location

[Isoform 1]: Mitochondrion.; [Isoform 2]: Cytoplasm. Nucleus.
Target Protein Families

NifU family
Target Tissue Specificity

Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta.
Target Research Area

Metabolism, Signal Transduction
Target Synonyms

2310020H20Rik; HML; hnifU; Iron sulfur cluster assembly enzyme ISCU mitochondrial; Iron sulfur cluster scaffold homolog (E. coli); Iron sulfur cluster scaffold homolog; Iron-sulfur cluster assembly enzyme ISCU; Iscu; IscU iron sulfur cluster scaffold homolog; ISCU_HUMAN; ISU2; MGC74517; mitochondrial; NIFU; NifU like N terminal domain containing; NifU like N terminal domain containing protein; NifU like protein; NifU-like N-terminal domain-containing protein; NifU-like protein; NIFUN; Nitrogen fixation cluster like; OTTHUMP00000238760; OTTHUMP00000238761; OTTHUMP00000238762; OTTHUMP00000238764; OTTHUMP00000238765
Target Background

This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1.

Recombinant Human Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU)

Specifications

Immunogen Information

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